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I strongly believe that it's not so much the precise ISA that is important, but rather the thought processes involved in understanding the structure of a block of assembler.
I started developing with the lowly 8 bitters like the 6502, Z80 and 8031 many moons ago, then moved on to 16 bit. The move to 32 bit was really quite straightforward and I can at least grasp the basics of what a 64 bit block of code is doing.
Of course, knowledge of a platform you want to fully appreciate will take time, and that will take effort and patience - but those basics will forever be important.
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