I had never unpacked new aspr's, so my words my sound stupid, but here are some common ideas:
First of all, what you mean by 'application dont run'?
Do you get an error message or app just quits?
If you get a standart windows error, then maybe there is a problem with imports. You can try peverify (see attach) to find whats wrong in your exe. If app just ends sliently, try to break on ExitProcess or TerminateProcess funcs to find a code that executes them.
Then you can try to use a cryptocheck tool by Alephz (attached cc.rar), it 'll show you if program use control sum check.
If nothing helps try to trace packed prog and unpacked to find what differs. you can save trace log in SI (with SymbolLoader) if you disable Code Window first (with 'WC' command)
anyway, it seems to me, that program is trying to use some funcs that were in aspr body when the app was packed (aspr API?)