Personally, I think there is one major thing that will cut down on spyware + ad-aware:
MOZILLA FIREFOX!
www.mozilla.org

FireFox helps termendously with spyware, because it's alot more secure than Micro$ofts Internet Disaster.

Also, Kaspersky Anti-Virus has an option (extended Database), and it will scan for riskware, pornware, ad-ware, spyware, etc...
Ad-Aware SE Pro is also good.

I havn't had a virus in over 1 1/2 years, since I got kaspersky, but i've found near 80+ nasty viruses, including the sasser worm (BTW, their's a new explot of it going around!), Blaster / Lovesan, and alot of other dangerous viruses.