What do you mean by "can't be debugged"? Obviously the owner of X64DBG can answer better, but certain operations, such as setting x64dbg as JIT debugger, require elevation to work. What user context are you running each debugger under? Are you attaching or trying to load PSR EXE from debugger? Several variables... OllyDBG also have requirements and tells you at start of debugger (window pops up) if you are not running under admin context because some operations will fail.
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